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Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

BACKGROUND: Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug. To better understand this variability, the objective of this study was to predict brain extracellular fluid (ECF) concentrations and receptor...

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Detalles Bibliográficos
Autores principales:	Li, Claire H, Stratford, Robert E, Velez de Mendizabal, Nieves, Cremers, Thomas IFH, Pollock, Bruce G, Mulsant, Benoit H, Remington, Gary, Bies, Robert R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261612/ https://www.ncbi.nlm.nih.gov/pubmed/25142323 http://dx.doi.org/10.1186/1479-5876-12-203

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