Pretreatment of Human Cervicovaginal Mucus with Pluronic F127 Enhances Nanoparticle Penetration without Compromising Mucus Barrier Properties to Herpes Simplex Virus

[Image: see text] Mucosal drug delivery nanotechnologies are limited by the mucus barrier that protects nearly all epithelial surfaces not covered with skin. Most polymeric nanoparticles, including polystyrene nanoparticles (PS), strongly adhere to mucus, thereby limiting penetration and facilitatin...

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Detalles Bibliográficos
Autores principales: Ensign, Laura M., Lai, Samuel K., Wang, Ying-Ying, Yang, Ming, Mert, Olcay, Hanes, Justin, Cone, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261994/
https://www.ncbi.nlm.nih.gov/pubmed/25347518
http://dx.doi.org/10.1021/bm501419z

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