Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment

We recently showed that Mycobacterium leprae (ML) is able to induce lipid droplet formation in infected macrophages. We herein confirm that cholesterol (Cho) is one of the host lipid molecules that accumulate in ML-infected macrophages and investigate the effects of ML on cellular Cho metabolism res...

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Detalles Bibliográficos
Autores principales: Mattos, Katherine A, Oliveira, Viviane C G, Berrêdo-Pinho, Marcia, Amaral, Julio J, Antunes, Luis Caetano M, Melo, Rossana C N, Acosta, Chyntia C D, Moura, Danielle F, Olmo, Roberta, Han, Jun, Rosa, Patricia S, Almeida, Patrícia E, Finlay, B Brett, Borchers, Christoph H, Sarno, Euzenir N, Bozza, Patricia T, Atella, Georgia C, Pessolani, Maria Cristina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262048/
https://www.ncbi.nlm.nih.gov/pubmed/24552180
http://dx.doi.org/10.1111/cmi.12279

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