Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted p...

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Autores principales: Gehre, Florian, Ejo, Mebrat, Fissette, Kristina, de Rijk, Pim, Uwizeye, Cécile, Nduwamahoro, Elie, Goovaerts, Odin, Affolabi, Dissou, Gninafon, Martin, Lingoupou, Fanny M., Barry, Mamadou Dian, Sow, Oumou, Merle, Corinne, Olliaro, Piero, Ba, Fatoumata, Sarr, Marie, Piubello, Alberto, Noeske, Juergen, Antonio, Martin, Rigouts, Leen, de Jong, Bouke C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262193/
https://www.ncbi.nlm.nih.gov/pubmed/25493429
http://dx.doi.org/10.1371/journal.pone.0110393
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author Gehre, Florian
Ejo, Mebrat
Fissette, Kristina
de Rijk, Pim
Uwizeye, Cécile
Nduwamahoro, Elie
Goovaerts, Odin
Affolabi, Dissou
Gninafon, Martin
Lingoupou, Fanny M.
Barry, Mamadou Dian
Sow, Oumou
Merle, Corinne
Olliaro, Piero
Ba, Fatoumata
Sarr, Marie
Piubello, Alberto
Noeske, Juergen
Antonio, Martin
Rigouts, Leen
de Jong, Bouke C
author_facet Gehre, Florian
Ejo, Mebrat
Fissette, Kristina
de Rijk, Pim
Uwizeye, Cécile
Nduwamahoro, Elie
Goovaerts, Odin
Affolabi, Dissou
Gninafon, Martin
Lingoupou, Fanny M.
Barry, Mamadou Dian
Sow, Oumou
Merle, Corinne
Olliaro, Piero
Ba, Fatoumata
Sarr, Marie
Piubello, Alberto
Noeske, Juergen
Antonio, Martin
Rigouts, Leen
de Jong, Bouke C
author_sort Gehre, Florian
collection PubMed
description In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
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spelling pubmed-42621932014-12-15 Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa Gehre, Florian Ejo, Mebrat Fissette, Kristina de Rijk, Pim Uwizeye, Cécile Nduwamahoro, Elie Goovaerts, Odin Affolabi, Dissou Gninafon, Martin Lingoupou, Fanny M. Barry, Mamadou Dian Sow, Oumou Merle, Corinne Olliaro, Piero Ba, Fatoumata Sarr, Marie Piubello, Alberto Noeske, Juergen Antonio, Martin Rigouts, Leen de Jong, Bouke C PLoS One Research Article In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region. Public Library of Science 2014-12-10 /pmc/articles/PMC4262193/ /pubmed/25493429 http://dx.doi.org/10.1371/journal.pone.0110393 Text en © 2014 Gehre et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gehre, Florian
Ejo, Mebrat
Fissette, Kristina
de Rijk, Pim
Uwizeye, Cécile
Nduwamahoro, Elie
Goovaerts, Odin
Affolabi, Dissou
Gninafon, Martin
Lingoupou, Fanny M.
Barry, Mamadou Dian
Sow, Oumou
Merle, Corinne
Olliaro, Piero
Ba, Fatoumata
Sarr, Marie
Piubello, Alberto
Noeske, Juergen
Antonio, Martin
Rigouts, Leen
de Jong, Bouke C
Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title_full Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title_fullStr Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title_full_unstemmed Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title_short Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
title_sort shifts in mycobacterial populations and emerging drug-resistance in west and central africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262193/
https://www.ncbi.nlm.nih.gov/pubmed/25493429
http://dx.doi.org/10.1371/journal.pone.0110393
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