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NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and β-catenin accumulation

BACKGROUND: Adrenogonadal cell growth and differentiation are controlled by nuclear receptor NR5A1 (Ad4BP/SF-1) that regulates the expression of adrenal and gonadal genes. In addition, SF-1 also resides in the centrosome and controls centrosome homeostasis by restricting the activity of centrosomal...

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Detalles Bibliográficos
Autores principales:	Wang, Chia-Yih, Lai, Pao-Yen, Chen, Ting-Yu, Chung, Bon-chu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262199/ https://www.ncbi.nlm.nih.gov/pubmed/25421435 http://dx.doi.org/10.1186/s12964-014-0055-9

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