BAY 87–2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

BACKGROUND: The transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor of mitochondrial complex I and hypoxia-induced HIF-1 activity BAY-87-2243, on tumor micro...

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Detalles Bibliográficos
Autores principales: Helbig, Linda, Koi, Lydia, Brüchner, Kerstin, Gurtner, Kristin, Hess-Stumpp, Holger, Unterschemmann, Kerstin, Baumann, Michael, Zips, Daniel, Yaromina, Ala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262387/
https://www.ncbi.nlm.nih.gov/pubmed/25234922
http://dx.doi.org/10.1186/1748-717X-9-207

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