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Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells

Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti-proliferative and chemopreventive properties. Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with the isoquinoline alkaloid berberine (0.3–6 µM) inhibi...

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Detalles Bibliográficos
Autores principales:	Ming, Ming, Sinnett-Smith, James, Wang, Jia, Soares, Heloisa P., Young, Steven H., Eibl, Guido, Rozengurt, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262417/ https://www.ncbi.nlm.nih.gov/pubmed/25493642 http://dx.doi.org/10.1371/journal.pone.0114573

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