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Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation

Germline mutations in the PTEN tumor-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-H50R) are associated with a subset of Cowden syndrome and Cowden syndrome-like individuals (CS/CSL) and confer high risk of breast, thyroid and other cancers. Howev...

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Detalles Bibliográficos
Autores principales:	Yu, Wanfeng, He, Xin, Ni, Ying, Ngeow, Joanne, Eng, Charis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262496/ https://www.ncbi.nlm.nih.gov/pubmed/25149476 http://dx.doi.org/10.1093/hmg/ddu425

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