Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith–Wiedemann syndrome with epimutations

PURPOSE: Expression of imprinted genes is regulated by DNA methylation of differentially methylated regions (DMRs). Beckwith–Wiedemann syndrome is an imprinting disorder caused by epimutations of DMRs at 11p15.5. To date, multiple methylation defects have been reported in Beckwith–Wiedemann syndrome...

Descripción completa

Detalles Bibliográficos
Autores principales: Maeda, Toshiyuki, Higashimoto, Ken, Jozaki, Kosuke, Yatsuki, Hitomi, Nakabayashi, Kazuhiko, Makita, Yoshio, Tonoki, Hidefumi, Okamoto, Nobuhiko, Takada, Fumio, Ohashi, Hirofumi, Migita, Makoto, Kosaki, Rika, Matsubara, Keiko, Ogata, Tsutomu, Matsuo, Muneaki, Hamasaki, Yuhei, Ohtsuka, Yasufumi, Nishioka, Kenichi, Joh, Keiichiro, Mukai, Tsunehiro, Hata, Kenichiro, Soejima, Hidenobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262761/
https://www.ncbi.nlm.nih.gov/pubmed/24810686
http://dx.doi.org/10.1038/gim.2014.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262761/
https://www.ncbi.nlm.nih.gov/pubmed/24810686
http://dx.doi.org/10.1038/gim.2014.46

Ejemplares similares