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Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent

BACKGROUND: Idiopathic pulmonary fibrosis is a common and invariably fatal disease with limited therapeutic options. Ca(2+)-activated K(Ca)3.1 potassium channels play a key role in promoting TGFβ1 and bFGF-dependent profibrotic responses in human lung myofibroblasts (HLMFs). We hypothesised that K(C...

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Detalles Bibliográficos
Autores principales:	Roach, Katy M, Wulff, Heike, Feghali-Bostwick, Carol, Amrani, Yassine, Bradding, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263015/ https://www.ncbi.nlm.nih.gov/pubmed/25476248 http://dx.doi.org/10.1186/s12931-014-0155-5

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