Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells are capable of counteracting these signals through mechanisms that are largely unknown. Here we show that the prolyl hydroxylase PHD3 restrains tumour growth in response t...

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Detalles Bibliográficos
Autores principales: Henze, Anne-Theres, Garvalov, Boyan K., Seidel, Sascha, Cuesta, Angel M., Ritter, Mathias, Filatova, Alina, Foss, Franziska, Dopeso, Higinio, Essmann, Clara L., Maxwell, Patrick H., Reifenberger, Guido, Carmeliet, Peter, Acker-Palmer, Amparo, Acker, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263145/
https://www.ncbi.nlm.nih.gov/pubmed/25420773
http://dx.doi.org/10.1038/ncomms6582

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