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Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells are capable of counteracting these signals through mechanisms that are largely unknown. Here we show that the prolyl hydroxylase PHD3 restrains tumour growth in response t...
Autores principales: | Henze, Anne-Theres, Garvalov, Boyan K., Seidel, Sascha, Cuesta, Angel M., Ritter, Mathias, Filatova, Alina, Foss, Franziska, Dopeso, Higinio, Essmann, Clara L., Maxwell, Patrick H., Reifenberger, Guido, Carmeliet, Peter, Acker-Palmer, Amparo, Acker, Till |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263145/ https://www.ncbi.nlm.nih.gov/pubmed/25420773 http://dx.doi.org/10.1038/ncomms6582 |
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