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The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
Host-adaptive strategies, such as the E627K substitution in the PB2 protein, are critical for replication of avian influenza A viruses in mammalian hosts. Here we show that mutation PB2-K526R is present in some human H7N9 influenza isolates, in nearly 80% of H5N1 human isolates from Indonesia and, i...
Autores principales: | Song, Wenjun, Wang, Pui, Mok, Bobo Wing-Yee, Lau, Siu-Ying, Huang, Xiaofeng, Wu, Wai-Lan, Zheng, Min, Wen, Xi, Yang, Shigui, Chen, Yu, Li, Lanjuan, Yuen, Kwok-Yung, Chen, Honglin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263149/ https://www.ncbi.nlm.nih.gov/pubmed/25409547 http://dx.doi.org/10.1038/ncomms6509 |
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