Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

RNA polymerase II (RNAPII) pausing/termination shortly after initiation is a hallmark of gene regulation. Here, we show that negative elongation factor (NELF) interacts with Integrator complex subunits (INTScom), RNAPII and Spt5. The interaction between NELF and INTScom subunits is RNA and DNA indep...

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Detalles Bibliográficos
Autores principales: Stadelmayer, Bernd, Micas, Gaël, Gamot, Adrien, Martin, Pascal, Malirat, Nathalie, Koval, Slavik, Raffel, Raoul, Sobhian, Bijan, Severac, Dany, Rialle, Stéphanie, Parrinello, Hugues, Cuvier, Olivier, Benkirane, Monsef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263189/
https://www.ncbi.nlm.nih.gov/pubmed/25410209
http://dx.doi.org/10.1038/ncomms6531

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