Cargando…

Imputation and quality control steps for combining multiple genome-wide datasets

The electronic MEdical Records and GEnomics (eMERGE) network brings together DNA biobanks linked to electronic health records (EHRs) from multiple institutions. Approximately 51,000 DNA samples from distinct individuals have been genotyped using genome-wide SNP arrays across the nine sites of the ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Shefali S., de Andrade, Mariza, Tromp, Gerard, Kuivaniemi, Helena, Pugh, Elizabeth, Namjou-Khales, Bahram, Mukherjee, Shubhabrata, Jarvik, Gail P., Kottyan, Leah C., Burt, Amber, Bradford, Yuki, Armstrong, Gretta D., Derr, Kimberly, Crawford, Dana C., Haines, Jonathan L., Li, Rongling, Crosslin, David, Ritchie, Marylyn D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263197/ https://www.ncbi.nlm.nih.gov/pubmed/25566314 http://dx.doi.org/10.3389/fgene.2014.00370

Ejemplares similares

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records
por: Crosslin, David R., et al.
Publicado: (2014)

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016)

eMERGEing progress in genomics—the first seven years
por: Crawford, Dana C., et al.
Publicado: (2014)

The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research
por: Ritchie, Marylyn D., et al.
Publicado: (2015)

Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network
por: Hall, Molly A, et al.
Publicado: (2015)

Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index
por: Hui, Daniel, et al.
Publicado: (2023)

The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype
por: Stanaway, Ian B., et al.
Publicado: (2018)

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis
por: Namjou, Bahram, et al.
Publicado: (2014)

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases
por: Verma, Anurag, et al.
Publicado: (2016)

Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network
por: Crosslin, David R., et al.
Publicado: (2015)

Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female‐Specific Health Conditions
por: Xiao, Brenda, et al.
Publicado: (2023)

A GWAS Study on Liver Function Test Using eMERGE Network Participants
por: Namjou, Bahram, et al.
Publicado: (2015)

Imputation methods for missing data for polygenic models
por: Fridley, Brooke, et al.
Publicado: (2003)

Another Round of “Clue” to Uncover the Mystery of Complex Traits
por: Verma, Shefali Setia, et al.
Publicado: (2018)

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
por: Namjou, Bahram, et al.
Publicado: (2019)

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population
por: Namjou, Bahram, et al.
Publicado: (2014)

Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network
por: Gallego, Carlos J., et al.
Publicado: (2015)

Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network
por: Malinowski, Jennifer R., et al.
Publicado: (2014)

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future
por: Gottesman, Omri, et al.
Publicado: (2013)

Analysis pipeline for the epistasis search – statistical versus biological filtering
por: Sun, Xiangqing, et al.
Publicado: (2014)

A simulation study investigating power estimates in phenome-wide association studies
por: Verma, Anurag, et al.
Publicado: (2018)

Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression()
por: Li, Binglan, et al.
Publicado: (2018)

Assessment of genotype imputation methods
por: Biernacka, Joanna M, et al.
Publicado: (2009)

ADEPT: Autoencoder with differentially expressed genes and imputation for robust spatial transcriptomics clustering
por: Hu, Yunfei, et al.
Publicado: (2023)

Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies
por: Li, Binglan, et al.
Publicado: (2019)

Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants
por: Kim, Daniel Seung, et al.
Publicado: (2014)

Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data
por: Mosley, Jonathan D., et al.
Publicado: (2013)

Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci
por: Ritchie, Marylyn D., et al.
Publicado: (2014)

A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes
por: Liu, Ge, et al.
Publicado: (2021)

Molecular basis and genetic predisposition to intracranial aneurysm
por: Tromp, Gerard, et al.
Publicado: (2014)

Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection
por: Ferar, Kathleen, et al.
Publicado: (2023)

Author Correction: Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection
por: Ferar, Kathleen, et al.
Publicado: (2023)

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium
por: Verma, Shefali Setia, et al.
Publicado: (2016)

46,X,del(X)(q13) Turner's Syndrome Female with Systemic Lupus Erythematosus in a Pedigree Multiplex for SLE
por: Cooney, Carisa M., et al.
Publicado: (2009)

Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients
por: Sun, Quan, et al.
Publicado: (2022)

Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population
por: Schurz, Haiko, et al.
Publicado: (2019)

Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202
por: Verma, Anurag, et al.
Publicado: (2017)

Imputation of missing genotypes: an empirical evaluation of IMPUTE
por: Zhao, Zhenming, et al.
Publicado: (2008)

Molgenis-impute: imputation pipeline in a box
por: Kanterakis, Alexandros, et al.
Publicado: (2015)

Combining Multiple Imputation and Inverse-Probability Weighting
por: Seaman, Shaun R, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_p1li93l61cfsuin1a0ikvs02up