MicroRNA-mediated regulation of KRAS in cancer

While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Kim, Minlee, Slack, Frank J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263212/
https://www.ncbi.nlm.nih.gov/pubmed/25433809
http://dx.doi.org/10.1186/s13045-014-0084-2
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author Kim, Minlee
Slack, Frank J
author_facet Kim, Minlee
Slack, Frank J
author_sort Kim, Minlee
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description While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
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spelling pubmed-42632122014-12-12 MicroRNA-mediated regulation of KRAS in cancer Kim, Minlee Slack, Frank J J Hematol Oncol Research Highlight While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation. BioMed Central 2014-11-30 /pmc/articles/PMC4263212/ /pubmed/25433809 http://dx.doi.org/10.1186/s13045-014-0084-2 Text en © Kim and Slack; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Kim, Minlee
Slack, Frank J
MicroRNA-mediated regulation of KRAS in cancer
title MicroRNA-mediated regulation of KRAS in cancer
title_full MicroRNA-mediated regulation of KRAS in cancer
title_fullStr MicroRNA-mediated regulation of KRAS in cancer
title_full_unstemmed MicroRNA-mediated regulation of KRAS in cancer
title_short MicroRNA-mediated regulation of KRAS in cancer
title_sort microrna-mediated regulation of kras in cancer
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263212/
https://www.ncbi.nlm.nih.gov/pubmed/25433809
http://dx.doi.org/10.1186/s13045-014-0084-2
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