Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform a two-stage siRNA-based functional scree...

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Detalles Bibliográficos
Autores principales: Ziv, Omer, Zeisel, Amit, Mirlas-Neisberg, Nataly, Swain, Umakanta, Nevo, Reinat, Ben-Chetrit, Nir, Martelli, Maria Paola, Rossi, Roberta, Schiesser, Stefan, Canman, Christine E., Carell, Thomas, Geacintov, Nicholas E., Falini, Brunangelo, Domany, Eytan, Livneh, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263322/
https://www.ncbi.nlm.nih.gov/pubmed/25421715
http://dx.doi.org/10.1038/ncomms6437

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