Cargando…

Pyranose Dehydrogenase Ligand Promiscuity: A Generalized Approach to Simulate Monosaccharide Solvation, Binding, and Product Formation

The flavoenzyme pyranose dehydrogenase (PDH) from the litter decomposing fungus Agaricus meleagris oxidizes many different carbohydrates occurring during lignin degradation. This promiscuous substrate specificity makes PDH a promising catalyst for bioelectrochemical applications. A generalized appro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Graf, Michael M. H., Zhixiong, Lin, Bren, Urban, Haltrich, Dietmar, van Gunsteren, Wilfred F., Oostenbrink, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263366/ https://www.ncbi.nlm.nih.gov/pubmed/25500811 http://dx.doi.org/10.1371/journal.pcbi.1003995

Ejemplares similares

Molecular dynamics simulations give insight into d-glucose dioxidation at C2 and C3 by Agaricus meleagris pyranose dehydrogenase
por: Graf, Michael M. H., et al.
Publicado: (2013)

Reaction of pyranose dehydrogenase from Agaricus meleagris with its carbohydrate substrates
por: Graf, Michael M.H., et al.
Publicado: (2015)

Engineering of Pyranose Dehydrogenase for Increased Oxygen Reactivity
por: Krondorfer, Iris, et al.
Publicado: (2014)

Pyranose Dehydrogenase from Agaricus campestris and Agaricus xanthoderma: Characterization and Applications in Carbohydrate Conversions
por: Staudigl, Petra, et al.
Publicado: (2013)

Simple and efficient expression of Agaricus meleagris pyranose dehydrogenase in Pichia pastoris
por: Sygmund, Christoph, et al.
Publicado: (2011)

Characterization of three pyranose dehydrogenase isoforms from the litter-decomposing basidiomycete Leucoagaricus meleagris (syn. Agaricus meleagris)
por: Graf, Michael M. H., et al.
Publicado: (2016)

Agaricus meleagris pyranose dehydrogenase: Influence of covalent FAD linkage on catalysis and stability
por: Krondorfer, Iris, et al.
Publicado: (2014)

Pyranose Ring Puckering Thermodynamics for Glycan Monosaccharides Associated with Vertebrate Proteins
por: Guvench, Olgun, et al.
Publicado: (2021)

Characterization of pyranose oxidase variants for bioelectrocatalytic applications
por: Abrera, Annabelle T., et al.
Publicado: (2020)

Biochemical Characterization of Pyranose Oxidase from Streptomyces canus—Towards a Better Understanding of Pyranose Oxidase Homologues in Bacteria
por: Kostelac, Anja, et al.
Publicado: (2022)

Versatile Oxidase and Dehydrogenase Activities of Bacterial Pyranose 2-Oxidase Facilitate Redox Cycling with Manganese Peroxidase In Vitro
por: Herzog, Peter L., et al.
Publicado: (2019)

Engineering Pyranose 2-Oxidase for Modified Oxygen Reactivity
por: Brugger, Dagmar, et al.
Publicado: (2014)

On the use of multiple‐time‐step algorithms to save computing effort in molecular dynamics simulations of proteins
por: Pechlaner, Maria, et al.
Publicado: (2021)

Electrochemical characterization of the pyranose 2-oxidase variant N593C shows a complete loss of the oxidase function with full preservation of substrate (dehydrogenase) activity
por: Brugger, Dagmar, et al.
Publicado: (2016)

The 1.6 Å Crystal Structure of Pyranose Dehydrogenase from Agaricus meleagris Rationalizes Substrate Specificity and Reveals a Flavin Intermediate
por: Tan, Tien Chye, et al.
Publicado: (2013)

Quantitative Comparison of Pyranose Dehydrogenase Action on Diverse Xylooligosaccharides
por: Karppi, Johanna, et al.
Publicado: (2020)

Molecular dynamics simulations and free energy calculations of netropsin and distamycin binding to an AAAAA DNA binding site
por: Dolenc, Jožica, et al.
Publicado: (2005)

Evaluation of different expression systems for the heterologous expression of pyranose 2-oxidase from Trametes multicolor in E. coli
por: Spadiut, Oliver, et al.
Publicado: (2010)

Oxidation of Phe454 in the Gating Segment Inactivates Trametes multicolor Pyranose Oxidase during Substrate Turnover
por: Halada, Petr, et al.
Publicado: (2016)

Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion
por: Tan, Tien Chye, et al.
Publicado: (2014)

Characterisation of recombinant pyranose oxidase from the cultivated mycorrhizal basidiomycete Lyophyllum shimeji (hon-shimeji)
por: Salaheddin, Clara, et al.
Publicado: (2010)

Implicit Solvation Parameters Derived from Explicit Water Forces in Large-Scale Molecular Dynamics Simulations
por: Kleinjung, Jens, et al.
Publicado: (2012)

Crystal structures of Phanerochaete chrysosporium pyranose 2-oxidase suggest that the N-terminus acts as a propeptide that assists in homotetramer assembly()
por: Hassan, Noor, et al.
Publicado: (2013)

Promiscuous Ligands
por: McGovern, S.L.
Publicado: (2007)

The Pyrroloquinoline-Quinone-Dependent Pyranose Dehydrogenase from Coprinopsis cinerea Drives Lytic Polysaccharide Monooxygenase Action
por: Várnai, Anikó, et al.
Publicado: (2018)

Could Microwave Irradiation Cause Misfolding of Peptides?
por: Gladovic, Martin, et al.
Publicado: (2020)

Further Insights into the Catalytical Properties of Deglycosylated Pyranose Dehydrogenase from Agaricus meleagris Recombinantly Expressed in Pichia pastoris
por: Yakovleva, Maria E., et al.
Publicado: (2013)

Updated restraint dictionaries for carbohydrates in the pyranose form
por: Atanasova, Mihaela, et al.
Publicado: (2022)

On the use of intra‐molecular distance and angle constraints to lengthen the time step in molecular and stochastic dynamics simulations of proteins
por: Pechlaner, Maria, et al.
Publicado: (2021)

BFMP: A Method for Discretizing and Visualizing Pyranose Conformations
por: Makeneni, Spandana, et al.
Publicado: (2014)

The price of flexibility – a case study on septanoses as pyranose mimetics
por: Sager, Christoph P., et al.
Publicado: (2017)

On the pitfalls of peer review
por: van Gunsteren, Wilfred
Publicado: (2015)

Enhancing the promiscuity of a member of the Caspase protease family by rational design
por: Öhlknecht, Christoph, et al.
Publicado: (2020)

Characterization of a Novel PQQ-Dependent Quinohemoprotein Pyranose Dehydrogenase from Coprinopsis cinerea Classified into Auxiliary Activities Family 12 in Carbohydrate-Active Enzymes
por: Takeda, Kouta, et al.
Publicado: (2015)

Net charge changes in the calculation of relative ligand-binding free energies via classical atomistic molecular dynamics simulation
por: Reif, Maria M, et al.
Publicado: (2014)

Molecular dynamics simulation or structure refinement of proteins: are solvent molecules required? A case study using hen lysozyme
por: Pechlaner, Maria, et al.
Publicado: (2022)

Monosaccharide autoxidation in health and disease.
por: Thornalley, P J
Publicado: (1985)

Flavin Mononucleotide-Dependent l-Lactate Dehydrogenases: Expanding the Toolbox of Enzymes for l-Lactate Biosensors
por: Tsvik, Lidiia, et al.
Publicado: (2022)

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases
por: Swanson, Christopher R. B., et al.
Publicado: (2023)

Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands
por: Ng, Hui Wen, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dpctgppvjpp9vquvnubivoe6m9