The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes

The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation phenotypes). We found that, in these mutants, incomplete NER reactions lead to replication...

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Detalles Bibliográficos
Autores principales: Herrera-Moyano, Emilia, Moriel-Carretero, María, Montelone, Beth A., Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263401/
https://www.ncbi.nlm.nih.gov/pubmed/25500814
http://dx.doi.org/10.1371/journal.pgen.1004859

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