Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of the Enzyme

[Image: see text] Among the different histone deacetylase (HDAC) isozymes, HDAC8 is the most highly malleable enzyme, and it exhibits the potential to accommodate structurally diverse ligands (albeit with moderate binding affinities) in its active site pocket. To probe the molecular basis of this fe...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Raushan K., Suzuki, Takayoshi, Mandal, Tanmay, Balsubramanian, Narayanaganesh, Haldar, Manas, Mueller, Dustin J., Strode, Jerrod A., Cook, Gregory, Mallik, Sanku, Srivastava, D. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263425/
https://www.ncbi.nlm.nih.gov/pubmed/25407689
http://dx.doi.org/10.1021/bi500711x

Ejemplares similares

Ejemplares similares