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Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents

Ligand conjugation is an attractive approach to rationally modify the poor pharmacokinetic behavior and cellular uptake properties of antisense oligonucleotides. Polyethylene glycol (PEG) attachment is a method to increase solubility of oligonucleotides and prevent the rapid elimination, thus increa...

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Detalles Bibliográficos
Autores principales:	Shokrzadeh, Nasrin, Winkler, Anna-Maria, Dirin, Mehrdad, Winkler, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263527/ https://www.ncbi.nlm.nih.gov/pubmed/25453815 http://dx.doi.org/10.1016/j.bmcl.2014.10.045

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