Short chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway

Microbial metabolites such as short chain fatty acids (SCFAs) are highly produced in the intestine and potentially regulate the immune system. We studied the function of SCFAs in regulation of T cell differentiation into effector and regulatory T cells. We report that SCFAs can directly promote T ce...

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Detalles Bibliográficos
Autores principales: Park, Jeongho, Kim, Myunghoo, Kang, Seung G., Jannasch, Amber Hopf, Cooper, Bruce, Patterson, John, Kim, Chang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263689/
https://www.ncbi.nlm.nih.gov/pubmed/24917457
http://dx.doi.org/10.1038/mi.2014.44

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