A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...

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Detalles Bibliográficos
Autores principales: Andoniou, Christopher E., Sutton, Vivien R., Wikstrom, Matthew E., Fleming, Peter, Thia, Kevin Y. T., Matthews, Antony Y., Kaiserman, Dion, Schuster, Iona S., Coudert, Jerome D., Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I., Trapani, Joseph A., Degli-Esposti, Mariapia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263754/
https://www.ncbi.nlm.nih.gov/pubmed/25502180
http://dx.doi.org/10.1371/journal.ppat.1004526

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