Dramatic Potentiation of the Antiviral Activity of HIV Antibodies by Cholesterol Conjugation

The broadly neutralizing antibodies HIV 2F5 and 4E10, which bind to overlapping epitopes in the membrane-proximal external region of the fusion protein gp41, have been proposed to use a two-step mechanism for neutralization; first, they bind and preconcentrate at the viral membrane through their lon...

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Detalles Bibliográficos
Autores principales: Lacek, Krzysztof, Urbanowicz, Richard A., Troise, Fulvia, De Lorenzo, Claudia, Severino, Valeria, Di Maro, Antimo, Tarr, Alexander W., Ferrara, Francesca, Ploss, Alexander, Temperton, Nigel, Ball, Jonathan K., Nicosia, Alfredo, Cortese, Riccardo, Pessi, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263897/
https://www.ncbi.nlm.nih.gov/pubmed/25342747
http://dx.doi.org/10.1074/jbc.M114.591826

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