Cargando…

A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

Gene activation by the CRISPR/Cas9 system has the potential to enable new approaches to science and medicine, but the technology must be enhanced to robustly control cell behavior. We show that the fusion of two transactivation domains to Cas9 dramatically enhances gene activation to a level that is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chakraborty, Syandan, Ji, HaYeun, Kabadi, Ami M., Gersbach, Charles A., Christoforou, Nicolas, Leong, Kam W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264059/ https://www.ncbi.nlm.nih.gov/pubmed/25448066 http://dx.doi.org/10.1016/j.stemcr.2014.09.013

Ejemplares similares

Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis
por: Chakraborty, Syandan, et al.
Publicado: (2014)

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector
por: Kabadi, Ami M., et al.
Publicado: (2014)

Highly Specific Epigenome Editing by CRISPR/Cas9 Repressors for Silencing of Distal Regulatory Elements
por: Thakore, Pratiksha I., et al.
Publicado: (2015)

Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators
por: Kwon, Jennifer B., et al.
Publicado: (2020)

Multiplex CRISPR/Cas9-Based Genome Editing for Correction of Dystrophin Mutations that Cause Duchenne Muscular Dystrophy
por: Ousterout, David G., et al.
Publicado: (2015)

RNA-guided gene activation by CRISPR-Cas9-based transcription factors
por: Perez-Pinera, Pablo, et al.
Publicado: (2013)

Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage
por: Christoforou, Nicolas, et al.
Publicado: (2017)

HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute
por: Lao, Yeh‐Hsing, et al.
Publicado: (2018)

A Robust Strategy for Negative Selection of Cre-LoxP Recombination-Based Excision of Transgenes in Induced Pluripotent Stem Cells
por: Chakraborty, Syandan, et al.
Publicado: (2013)

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
por: Wang, Hong-Xia, et al.
Publicado: (2018)

Induced Pluripotent Stem Cell-Derived Cardiac Progenitors Differentiate to Cardiomyocytes and Form Biosynthetic Tissues
por: Christoforou, Nicolas, et al.
Publicado: (2013)

Targeted genome and epigenome editing using engineered TALE and CRISPR/Cas9 technologies
por: Gersbach, Charles A
Publicado: (2014)

Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange
por: Kelton, William, et al.
Publicado: (2017)

A light-inducible CRISPR/Cas9 system for control of endogenous gene activation
por: Polstein, Lauren R., et al.
Publicado: (2015)

Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators
por: Wang, Jianglin, et al.
Publicado: (2020)

Cell Reprogramming With CRISPR/Cas9 Based Transcriptional Regulation Systems
por: Shakirova, Ksenia M., et al.
Publicado: (2020)

RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
por: Thakore, Pratiksha I., et al.
Publicado: (2018)

Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
por: Kabadi, Ami M., et al.
Publicado: (2014)

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
por: Polstein, Lauren R., et al.
Publicado: (2015)

Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects
por: Deng, Shaohui, et al.
Publicado: (2020)

Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers
por: Hilton, Isaac B., et al.
Publicado: (2015)

Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
por: Zafar, Hamim, et al.
Publicado: (2020)

Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia
por: Pankowicz, Francis P., et al.
Publicado: (2016)

Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity
por: Aschenbrenner, Sabine, et al.
Publicado: (2020)

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
por: Klann, Tyler S., et al.
Publicado: (2017)

Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels
por: Jung, Youngmee, et al.
Publicado: (2015)

What is CRISPR/Cas9?
por: Redman, Melody, et al.
Publicado: (2016)

Advances in CRISPR/Cas9
por: Zhu, Youmin
Publicado: (2022)

Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter
por: Dicks, Amanda, et al.
Publicado: (2020)

The Advance of CRISPR-Cas9-Based and NIR/CRISPR-Cas9-Based Imaging System
por: Qiao, Huanhuan, et al.
Publicado: (2021)

Engineered CRISPR-Cas9 nucleases with altered PAM specificities
por: Kleinstiver, Benjamin P., et al.
Publicado: (2015)

Directed evolution of CRISPR-Cas9 to increase its specificity
por: Lee, Jungjoon K., et al.
Publicado: (2018)

Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors
por: Zhu, Jie, et al.
Publicado: (2017)

Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
por: Dong, Chen, et al.
Publicado: (2018)

Reshuffling yeast chromosomes with CRISPR/Cas9
por: Fleiss, Aubin, et al.
Publicado: (2019)

Simultaneous lineage tracing and cell-type identification using CRISPR/Cas9-induced genetic scars
por: Spanjaard, Bastiaan, et al.
Publicado: (2018)

CRISPR/Cas9-Mediated Gene Correction to Understand ALS
por: Yun, Yeomin, et al.
Publicado: (2020)

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
por: Hakim, Chady H., et al.
Publicado: (2021)

Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
por: Matjusaitis, Mantas, et al.
Publicado: (2019)

Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery
por: Luo, Nianan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pfvip0dl6ql8bjgnt519f08lt7