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A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

Gene activation by the CRISPR/Cas9 system has the potential to enable new approaches to science and medicine, but the technology must be enhanced to robustly control cell behavior. We show that the fusion of two transactivation domains to Cas9 dramatically enhances gene activation to a level that is...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Syandan, Ji, HaYeun, Kabadi, Ami M., Gersbach, Charles A., Christoforou, Nicolas, Leong, Kam W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264059/ https://www.ncbi.nlm.nih.gov/pubmed/25448066 http://dx.doi.org/10.1016/j.stemcr.2014.09.013

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