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Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide

OBJECTIVE: The curtailed knowledge about neonicotinoids that it has low affinity for vertebrate relative to insect nicotinic receptors is a major factor for its widespread use assuming that it is much safer than the previous generation insecticides. But literature regarding effect of thiamethoxam (s...

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Autores principales: Sinha, Suprita, Thaker, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264073/
https://www.ncbi.nlm.nih.gov/pubmed/25538329
http://dx.doi.org/10.4103/0253-7613.144910
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author Sinha, Suprita
Thaker, A. M.
author_facet Sinha, Suprita
Thaker, A. M.
author_sort Sinha, Suprita
collection PubMed
description OBJECTIVE: The curtailed knowledge about neonicotinoids that it has low affinity for vertebrate relative to insect nicotinic receptors is a major factor for its widespread use assuming that it is much safer than the previous generation insecticides. But literature regarding effect of thiamethoxam (second generation neonicotinoid)on immune system is not available. Also, there might be chances of interaction of heavy persistent metals in the water table with these pesticides. So, this study was undertaken with the objective to find immunotoxic alterations of lead acetate after exposure with thiamethoxam in animal model. MATERIALS AND METHODS: For this albino mice were randomly divided into 6 groups (numbered I to VI) each containing 6 mice. Animals of groups I and II were administered 87.1 mg/kg b.w.(body weight) and 43.5 mg/kg b.w. respectively of thiamethoxam. Group III animals, lead acetate was administered orally and IV and V mice were administered combination of lead acetate and thiamethoxam at higher and lower dose level for 28 days. The group VI was control group. On 29(th) day and humoral and cell mediated immune responses, TLC (Total leukocyte count), DLC (Differential leukocyte count), serum total protein, globulin and albumin, and histopathological studies were conducted. RESULT: The result obtained clearly indicated that on oral administration of thiamethoxam immunotoxicity was induced in mice in dose related manner. Lead acetate when administered for 28 days showed immunotoxic potential. Thiamethoxam and lead acetate when administered together did not lead to any new altered immunotoxic response but additive toxic effects of both were observed.
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spelling pubmed-42640732014-12-23 Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide Sinha, Suprita Thaker, A. M. Indian J Pharmacol Research Article OBJECTIVE: The curtailed knowledge about neonicotinoids that it has low affinity for vertebrate relative to insect nicotinic receptors is a major factor for its widespread use assuming that it is much safer than the previous generation insecticides. But literature regarding effect of thiamethoxam (second generation neonicotinoid)on immune system is not available. Also, there might be chances of interaction of heavy persistent metals in the water table with these pesticides. So, this study was undertaken with the objective to find immunotoxic alterations of lead acetate after exposure with thiamethoxam in animal model. MATERIALS AND METHODS: For this albino mice were randomly divided into 6 groups (numbered I to VI) each containing 6 mice. Animals of groups I and II were administered 87.1 mg/kg b.w.(body weight) and 43.5 mg/kg b.w. respectively of thiamethoxam. Group III animals, lead acetate was administered orally and IV and V mice were administered combination of lead acetate and thiamethoxam at higher and lower dose level for 28 days. The group VI was control group. On 29(th) day and humoral and cell mediated immune responses, TLC (Total leukocyte count), DLC (Differential leukocyte count), serum total protein, globulin and albumin, and histopathological studies were conducted. RESULT: The result obtained clearly indicated that on oral administration of thiamethoxam immunotoxicity was induced in mice in dose related manner. Lead acetate when administered for 28 days showed immunotoxic potential. Thiamethoxam and lead acetate when administered together did not lead to any new altered immunotoxic response but additive toxic effects of both were observed. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4264073/ /pubmed/25538329 http://dx.doi.org/10.4103/0253-7613.144910 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sinha, Suprita
Thaker, A. M.
Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title_full Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title_fullStr Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title_full_unstemmed Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title_short Study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
title_sort study on the impact of lead acetate pollutant on immunotoxicity produced by thiamethoxam pesticide
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264073/
https://www.ncbi.nlm.nih.gov/pubmed/25538329
http://dx.doi.org/10.4103/0253-7613.144910
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