Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy

Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-...

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Autores principales: Ksouda, Kamilia, Affes, Hanen, Atheymen, Rim, Ezzeddine, Mariem, Zeghal, Khaled, Hammami, Serria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264083/
https://www.ncbi.nlm.nih.gov/pubmed/25538339
http://dx.doi.org/10.4103/0253-7613.144940
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author Ksouda, Kamilia
Affes, Hanen
Atheymen, Rim
Ezzeddine, Mariem
Zeghal, Khaled
Hammami, Serria
author_facet Ksouda, Kamilia
Affes, Hanen
Atheymen, Rim
Ezzeddine, Mariem
Zeghal, Khaled
Hammami, Serria
author_sort Ksouda, Kamilia
collection PubMed
description Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.
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spelling pubmed-42640832014-12-23 Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy Ksouda, Kamilia Affes, Hanen Atheymen, Rim Ezzeddine, Mariem Zeghal, Khaled Hammami, Serria Indian J Pharmacol Drug Watch Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4264083/ /pubmed/25538339 http://dx.doi.org/10.4103/0253-7613.144940 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Ksouda, Kamilia
Affes, Hanen
Atheymen, Rim
Ezzeddine, Mariem
Zeghal, Khaled
Hammami, Serria
Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title_full Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title_fullStr Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title_full_unstemmed Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title_short Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
title_sort autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264083/
https://www.ncbi.nlm.nih.gov/pubmed/25538339
http://dx.doi.org/10.4103/0253-7613.144940
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