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Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity
White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264137/ https://www.ncbi.nlm.nih.gov/pubmed/25356508 http://dx.doi.org/10.3390/ijms151119760 |
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author | Barraco, Gloria Maria Luciano, Rosa Semeraro, Michela Prieto-Hontoria, Pedro L. Manco, Melania |
author_facet | Barraco, Gloria Maria Luciano, Rosa Semeraro, Michela Prieto-Hontoria, Pedro L. Manco, Melania |
author_sort | Barraco, Gloria Maria |
collection | PubMed |
description | White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and/or monitor the clinical response to therapeutic interventions. |
format | Online Article Text |
id | pubmed-4264137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42641372014-12-12 Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity Barraco, Gloria Maria Luciano, Rosa Semeraro, Michela Prieto-Hontoria, Pedro L. Manco, Melania Int J Mol Sci Review White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and/or monitor the clinical response to therapeutic interventions. MDPI 2014-10-29 /pmc/articles/PMC4264137/ /pubmed/25356508 http://dx.doi.org/10.3390/ijms151119760 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barraco, Gloria Maria Luciano, Rosa Semeraro, Michela Prieto-Hontoria, Pedro L. Manco, Melania Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title | Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title_full | Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title_fullStr | Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title_full_unstemmed | Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title_short | Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity |
title_sort | recently discovered adipokines and cardio-metabolic comorbidities in childhood obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264137/ https://www.ncbi.nlm.nih.gov/pubmed/25356508 http://dx.doi.org/10.3390/ijms151119760 |
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