Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.

Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, sh...

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Detalles Bibliográficos
Autores principales: Lee, Yeon-Ju, Lee, Jeong-Woo, Lee, Dong-Geun, Lee, Hyi-Seung, Kang, Jong Soon, Yun, Jieun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264154/
https://www.ncbi.nlm.nih.gov/pubmed/25375188
http://dx.doi.org/10.3390/ijms151120045
Descripción
Sumario:Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI(50) values down to 5.2 μM) against six human cancer cell lines.

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