Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.

Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, sh...

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Detalles Bibliográficos
Autores principales: Lee, Yeon-Ju, Lee, Jeong-Woo, Lee, Dong-Geun, Lee, Hyi-Seung, Kang, Jong Soon, Yun, Jieun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264154/
https://www.ncbi.nlm.nih.gov/pubmed/25375188
http://dx.doi.org/10.3390/ijms151120045
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author Lee, Yeon-Ju
Lee, Jeong-Woo
Lee, Dong-Geun
Lee, Hyi-Seung
Kang, Jong Soon
Yun, Jieun
author_facet Lee, Yeon-Ju
Lee, Jeong-Woo
Lee, Dong-Geun
Lee, Hyi-Seung
Kang, Jong Soon
Yun, Jieun
author_sort Lee, Yeon-Ju
collection PubMed
description Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI(50) values down to 5.2 μM) against six human cancer cell lines.
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spelling pubmed-42641542014-12-12 Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp. Lee, Yeon-Ju Lee, Jeong-Woo Lee, Dong-Geun Lee, Hyi-Seung Kang, Jong Soon Yun, Jieun Int J Mol Sci Article Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI(50) values down to 5.2 μM) against six human cancer cell lines. MDPI 2014-11-04 /pmc/articles/PMC4264154/ /pubmed/25375188 http://dx.doi.org/10.3390/ijms151120045 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yeon-Ju
Lee, Jeong-Woo
Lee, Dong-Geun
Lee, Hyi-Seung
Kang, Jong Soon
Yun, Jieun
Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title_full Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title_fullStr Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title_full_unstemmed Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title_short Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
title_sort cytotoxic sesterterpenoids isolated from the marine sponge scalarispongia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264154/
https://www.ncbi.nlm.nih.gov/pubmed/25375188
http://dx.doi.org/10.3390/ijms151120045
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