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Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264171/ https://www.ncbi.nlm.nih.gov/pubmed/25383678 http://dx.doi.org/10.3390/ijms151120355 |
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author | Zhong, Jianfeng He, Yuan Chen, Wenjiang Shui, Xiaorong Chen, Can Lei, Wei |
author_facet | Zhong, Jianfeng He, Yuan Chen, Wenjiang Shui, Xiaorong Chen, Can Lei, Wei |
author_sort | Zhong, Jianfeng |
collection | PubMed |
description | Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI. |
format | Online Article Text |
id | pubmed-4264171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42641712014-12-12 Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction Zhong, Jianfeng He, Yuan Chen, Wenjiang Shui, Xiaorong Chen, Can Lei, Wei Int J Mol Sci Article Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI. MDPI 2014-11-06 /pmc/articles/PMC4264171/ /pubmed/25383678 http://dx.doi.org/10.3390/ijms151120355 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhong, Jianfeng He, Yuan Chen, Wenjiang Shui, Xiaorong Chen, Can Lei, Wei Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title | Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title_full | Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title_fullStr | Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title_full_unstemmed | Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title_short | Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction |
title_sort | circulating microrna-19a as a potential novel biomarker for diagnosis of acute myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264171/ https://www.ncbi.nlm.nih.gov/pubmed/25383678 http://dx.doi.org/10.3390/ijms151120355 |
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