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Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differen...

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Detalles Bibliográficos
Autores principales: Zhong, Jianfeng, He, Yuan, Chen, Wenjiang, Shui, Xiaorong, Chen, Can, Lei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264171/
https://www.ncbi.nlm.nih.gov/pubmed/25383678
http://dx.doi.org/10.3390/ijms151120355
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author Zhong, Jianfeng
He, Yuan
Chen, Wenjiang
Shui, Xiaorong
Chen, Can
Lei, Wei
author_facet Zhong, Jianfeng
He, Yuan
Chen, Wenjiang
Shui, Xiaorong
Chen, Can
Lei, Wei
author_sort Zhong, Jianfeng
collection PubMed
description Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI.
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spelling pubmed-42641712014-12-12 Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction Zhong, Jianfeng He, Yuan Chen, Wenjiang Shui, Xiaorong Chen, Can Lei, Wei Int J Mol Sci Article Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI. MDPI 2014-11-06 /pmc/articles/PMC4264171/ /pubmed/25383678 http://dx.doi.org/10.3390/ijms151120355 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhong, Jianfeng
He, Yuan
Chen, Wenjiang
Shui, Xiaorong
Chen, Can
Lei, Wei
Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title_full Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title_fullStr Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title_full_unstemmed Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title_short Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
title_sort circulating microrna-19a as a potential novel biomarker for diagnosis of acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264171/
https://www.ncbi.nlm.nih.gov/pubmed/25383678
http://dx.doi.org/10.3390/ijms151120355
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