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The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored...

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Detalles Bibliográficos
Autores principales:	Kim, Jun-Tae, Jung, Seo Hee, Kang, Sun Young, Ryu, Chung-Kyu, Kang, Nam Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264174/ https://www.ncbi.nlm.nih.gov/pubmed/25383681 http://dx.doi.org/10.3390/ijms151120403

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