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Multiple Mechanisms Mediate Resistance to Sorafenib in Urothelial Cancer

Genetic and epigenetic changes in the mitogen activated protein kinase (MAPK) signaling render urothelial cancer a potential target for tyrosine kinase inhibitor (TKI) treatment. However, clinical trials of several TKIs failed to prove efficacy. In this context, we investigated changes in MAPK signa...

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Detalles Bibliográficos
Autores principales:	Knievel, Judith, Schulz, Wolfgang A., Greife, Annemarie, Hader, Christiane, Lübke, Tobias, Schmitz, Ingo, Albers, Peter, Niegisch, Günter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264180/ https://www.ncbi.nlm.nih.gov/pubmed/25387078 http://dx.doi.org/10.3390/ijms151120500

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