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Structure–Biological Function Relationship Extended to Mitotic Arrest-Deficient 2-Like Protein Mad2 Native and Mutants-New Opportunity for Genetic Disorder Control

Overexpression of mitotic arrest-deficient proteins Mad1 and Mad2, two components of spindle assembly checkpoint, is a risk factor for chromosomal instability (CIN) and a trigger of many genetic disorders. Mad2 transition from inactive open (O-Mad2) to active closed (C-Mad2) conformations or Mad2 bi...

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Detalles Bibliográficos
Autores principales:	Avram, Speranta, Milac, Adina, Mernea, Maria, Mihailescu, Dan, Putz, Mihai V., Buiu, Catalin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264231/ https://www.ncbi.nlm.nih.gov/pubmed/25411801 http://dx.doi.org/10.3390/ijms151121381

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