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A novel method for detection of HBVcccDNA in hepatocytes using rolling circle amplification combined with in situ PCR

BACKGROUND: Intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the original template for HBV replication. The persistence of cccDNA is responsible for the recurrence of HBV infection. The detection of cccDNA can help the development of new antiviral drugs against HBV rep...

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Detalles Bibliográficos
Autores principales:	Zhong, Yanwei, Hu, Shuangye, Xu, Chen, Zhao, Yulai, Xu, Dongping, Zhao, Yanqing, Zhao, Jingmin, Li, Zhibin, Zhang, Xiuchang, Zhang, Hongfei, Li, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264245/ https://www.ncbi.nlm.nih.gov/pubmed/25465805 http://dx.doi.org/10.1186/s12879-014-0608-y

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