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Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer
Cancer treatment is being revolutionized by the emergence of immunotherapies such as immune checkpoint inhibitors and therapeutic cancer vaccines. Prostate cancer is amenable to such therapeutic approaches. The improved understanding of the relationship between the immune system and tumors has allow...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264488/ https://www.ncbi.nlm.nih.gov/pubmed/25566495 http://dx.doi.org/10.3389/fonc.2014.00351 |
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author | Burotto, Mauricio Singh, Nishith Heery, Christopher R. Gulley, James L. Madan, Ravi A. |
author_facet | Burotto, Mauricio Singh, Nishith Heery, Christopher R. Gulley, James L. Madan, Ravi A. |
author_sort | Burotto, Mauricio |
collection | PubMed |
description | Cancer treatment is being revolutionized by the emergence of immunotherapies such as immune checkpoint inhibitors and therapeutic cancer vaccines. Prostate cancer is amenable to such therapeutic approaches. The improved understanding of the relationship between the immune system and tumors has allowed therapeutic targeting of immune checkpoints and tumor associated antigens to be developed. Furthermore, interventions used in prostate cancer are capable of impacting the immune system. As demonstrated by preclinical data and emerging clinical data, radiation therapy, anti-androgen therapy, and chemotherapy can be used with immunotherapies to obtain synergistic results. Current and future clinical trials will further investigate these principles as immunotherapeutics are combined with each other and standard therapies for optimal clinical utility. |
format | Online Article Text |
id | pubmed-4264488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42644882015-01-06 Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer Burotto, Mauricio Singh, Nishith Heery, Christopher R. Gulley, James L. Madan, Ravi A. Front Oncol Oncology Cancer treatment is being revolutionized by the emergence of immunotherapies such as immune checkpoint inhibitors and therapeutic cancer vaccines. Prostate cancer is amenable to such therapeutic approaches. The improved understanding of the relationship between the immune system and tumors has allowed therapeutic targeting of immune checkpoints and tumor associated antigens to be developed. Furthermore, interventions used in prostate cancer are capable of impacting the immune system. As demonstrated by preclinical data and emerging clinical data, radiation therapy, anti-androgen therapy, and chemotherapy can be used with immunotherapies to obtain synergistic results. Current and future clinical trials will further investigate these principles as immunotherapeutics are combined with each other and standard therapies for optimal clinical utility. Frontiers Media S.A. 2014-12-12 /pmc/articles/PMC4264488/ /pubmed/25566495 http://dx.doi.org/10.3389/fonc.2014.00351 Text en Copyright © 2014 Burotto, Singh, Heery, Gulley and Madan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Burotto, Mauricio Singh, Nishith Heery, Christopher R. Gulley, James L. Madan, Ravi A. Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title | Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title_full | Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title_fullStr | Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title_full_unstemmed | Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title_short | Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer |
title_sort | exploiting synergy: immune-based combinations in the treatment of prostate cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264488/ https://www.ncbi.nlm.nih.gov/pubmed/25566495 http://dx.doi.org/10.3389/fonc.2014.00351 |
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