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Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats

INTRODUCTION: Our previous studies demonstrated that 50-60 mmHg mean arterial blood pressure was the ideal target hypotension for uncontrolled hemorrhagic shock during the active hemorrhage in sexually mature rats. The ideal target resuscitation pressure for immature and older rats has not been dete...

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Autores principales: Li, Tao, Zhu, Yu, Tian, Kunlun, Xue, Mingying, Peng, Xiaoyong, Lan, Dan, Liu, Liangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264615/
https://www.ncbi.nlm.nih.gov/pubmed/24020401
http://dx.doi.org/10.1186/cc12888
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author Li, Tao
Zhu, Yu
Tian, Kunlun
Xue, Mingying
Peng, Xiaoyong
Lan, Dan
Liu, Liangming
author_facet Li, Tao
Zhu, Yu
Tian, Kunlun
Xue, Mingying
Peng, Xiaoyong
Lan, Dan
Liu, Liangming
author_sort Li, Tao
collection PubMed
description INTRODUCTION: Our previous studies demonstrated that 50-60 mmHg mean arterial blood pressure was the ideal target hypotension for uncontrolled hemorrhagic shock during the active hemorrhage in sexually mature rats. The ideal target resuscitation pressure for immature and older rats has not been determined. METHODS: To elucidate this issue, using uncontrolled hemorrhagic-shock rats of different ages and sexes (6 weeks, 14 weeks and 1.5 years representing pre-adult, adult and older rats, respectively), the resuscitation effects of different target pressures (40, 50, 60, 70 and 80 mmHg) on uncontrolled hemorrhagic shock during active hemorrhage and the age and sex differences were observed. RESULTS: Different target resuscitation pressures had different resuscitation outcomes for the same age and sex of rats. The optimal target resuscitation pressures for 6-week-old, 14-week-old and 1.5-year-old rats were 40 to 50 mmHg, 50 to 60 mmHg and 70 mmHg respectively. Ideal target resuscitation pressures were significantly superior to other resuscitation pressures in improving the hemodynamics, blood perfusion, organ function and animal survival of uncontrolled hemorrhagic-shock rats (P < 0.01). For same target resuscitation pressures, the beneficial effect on hemorrhagic shock had a significant age difference (P < 0.01) but no sex difference (P > 0.05). Different resuscitation pressures had no effect on coagulation function. CONCLUSION: Hemorrhagic-shock rats at different ages have different target resuscitation pressures during active hemorrhage. The ideal target resuscitation hypotension for 6-week-old, 14-week-old and 1.5-year-old rats was 40 to 50 mmHg, 50 to 60 mmHg and 70 mmHg, respectively. Their resuscitation effects have significant age difference but had no sex difference.
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spelling pubmed-42646152014-12-13 Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats Li, Tao Zhu, Yu Tian, Kunlun Xue, Mingying Peng, Xiaoyong Lan, Dan Liu, Liangming Crit Care Research INTRODUCTION: Our previous studies demonstrated that 50-60 mmHg mean arterial blood pressure was the ideal target hypotension for uncontrolled hemorrhagic shock during the active hemorrhage in sexually mature rats. The ideal target resuscitation pressure for immature and older rats has not been determined. METHODS: To elucidate this issue, using uncontrolled hemorrhagic-shock rats of different ages and sexes (6 weeks, 14 weeks and 1.5 years representing pre-adult, adult and older rats, respectively), the resuscitation effects of different target pressures (40, 50, 60, 70 and 80 mmHg) on uncontrolled hemorrhagic shock during active hemorrhage and the age and sex differences were observed. RESULTS: Different target resuscitation pressures had different resuscitation outcomes for the same age and sex of rats. The optimal target resuscitation pressures for 6-week-old, 14-week-old and 1.5-year-old rats were 40 to 50 mmHg, 50 to 60 mmHg and 70 mmHg respectively. Ideal target resuscitation pressures were significantly superior to other resuscitation pressures in improving the hemodynamics, blood perfusion, organ function and animal survival of uncontrolled hemorrhagic-shock rats (P < 0.01). For same target resuscitation pressures, the beneficial effect on hemorrhagic shock had a significant age difference (P < 0.01) but no sex difference (P > 0.05). Different resuscitation pressures had no effect on coagulation function. CONCLUSION: Hemorrhagic-shock rats at different ages have different target resuscitation pressures during active hemorrhage. The ideal target resuscitation hypotension for 6-week-old, 14-week-old and 1.5-year-old rats was 40 to 50 mmHg, 50 to 60 mmHg and 70 mmHg, respectively. Their resuscitation effects have significant age difference but had no sex difference. BioMed Central 2013 2013-09-10 /pmc/articles/PMC4264615/ /pubmed/24020401 http://dx.doi.org/10.1186/cc12888 Text en Copyright © 2013 Li et al. licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Li, Tao
Zhu, Yu
Tian, Kunlun
Xue, Mingying
Peng, Xiaoyong
Lan, Dan
Liu, Liangming
Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title_full Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title_fullStr Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title_full_unstemmed Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title_short Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
title_sort ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264615/
https://www.ncbi.nlm.nih.gov/pubmed/24020401
http://dx.doi.org/10.1186/cc12888
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