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Allelic Exclusion of TCR α-Chains upon Severe Restriction of Vα Repertoire

Development of thymocytes through the positive selection checkpoint requires the rearrangement and expression of a suitable T cell receptor (TCR) α-chain that can pair with the already-expressed β-chain to make a TCR that is selectable. That is, it must have sufficient affinity for self MHC-peptide...

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Detalles Bibliográficos
Autores principales:	Rybakin, Vasily, Westernberg, Luise, Fu, Guo, Kim, Hee-Ok, Ampudia, Jeanette, Sauer, Karsten, Gascoigne, Nicholas R. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264757/ https://www.ncbi.nlm.nih.gov/pubmed/25500569 http://dx.doi.org/10.1371/journal.pone.0114320

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