Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

Crohn's disease (CD) is a complex and highly heterogeneous chronic inflammatory disorder, primarily affecting the gastrointestinal tract. Genetic and functional studies have highlighted a key role for innate immunity in its pathogenesis. Profound systemic defects in innate immunity and acute in...

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Detalles Bibliográficos
Autores principales: Smith, Andrew M, Sewell, Gavin W, Levine, Adam P, Chew, Thean S, Dunne, Jenny, O'Shea, Nuala R, Smith, Philip J, Harrison, Penelope J, Macdonald, Carol M, Bloom, Stuart L, Segal, Anthony W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264909/
https://www.ncbi.nlm.nih.gov/pubmed/24943399
http://dx.doi.org/10.1111/imm.12338

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