Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition

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Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the gene is not known to be mutated or amplifie...

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Detalles Bibliográficos
Autores principales: Ulanet, Danielle B., Couto, Kiley, Jha, Abhishek, Choe, Sung, Wang, Amanda, Woo, Hin-Koon, Steadman, Mya, DeLaBarre, Byron, Gross, Stefan, Driggers, Edward, Dorsch, Marion, Hurov, Jonathan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264947/
https://www.ncbi.nlm.nih.gov/pubmed/25502225
http://dx.doi.org/10.1371/journal.pone.0115144
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