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Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan

Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include auto...

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Autores principales: Chen, Shih-Yin, Chen, Cheng-Hsu, Huang, Yu-Chuen, Chan, Chia-Jung, Chen, Da-Chung, Tsai, Fuu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265015/
https://www.ncbi.nlm.nih.gov/pubmed/25520922
http://dx.doi.org/10.7603/s40681-014-0009-y
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author Chen, Shih-Yin
Chen, Cheng-Hsu
Huang, Yu-Chuen
Chan, Chia-Jung
Chen, Da-Chung
Tsai, Fuu-Jen
author_facet Chen, Shih-Yin
Chen, Cheng-Hsu
Huang, Yu-Chuen
Chan, Chia-Jung
Chen, Da-Chung
Tsai, Fuu-Jen
author_sort Chen, Shih-Yin
collection PubMed
description Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include autoimmune disease, infection, drugs and malignancy. Three hypotheses about pathogenesis have surfaced: preformed immune complex, in situ immune complex formation, and auto-antibody against podocyte membrane antigen. Pathogenesis does involve immune complex formation with later deposition in sub-epithelial sites, but definite mechanism is still unknown. Several genes were recently proven associated with primary membranous nephropathy in Taiwan: IL-6, NPHS1, TLR-4, TLR-9, STAT4, and MYH9 . These may provide a useful tool for diagnosis and prognosis. This article reviews epidemiology and lends new information on KIRREL2 (rs443186 and rs447707) polymorphisms as underlying causes of MN; polymorphisms revealed by this study warrant further investigation.
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spelling pubmed-42650152014-12-15 Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan Chen, Shih-Yin Chen, Cheng-Hsu Huang, Yu-Chuen Chan, Chia-Jung Chen, Da-Chung Tsai, Fuu-Jen Biomedicine (Taipei) Review Article Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include autoimmune disease, infection, drugs and malignancy. Three hypotheses about pathogenesis have surfaced: preformed immune complex, in situ immune complex formation, and auto-antibody against podocyte membrane antigen. Pathogenesis does involve immune complex formation with later deposition in sub-epithelial sites, but definite mechanism is still unknown. Several genes were recently proven associated with primary membranous nephropathy in Taiwan: IL-6, NPHS1, TLR-4, TLR-9, STAT4, and MYH9 . These may provide a useful tool for diagnosis and prognosis. This article reviews epidemiology and lends new information on KIRREL2 (rs443186 and rs447707) polymorphisms as underlying causes of MN; polymorphisms revealed by this study warrant further investigation. China Medical University 2014-08-06 /pmc/articles/PMC4265015/ /pubmed/25520922 http://dx.doi.org/10.7603/s40681-014-0009-y Text en © China Medical University 2014 https://creativecommons.org/licenses/by/4.0/ Open Access. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Chen, Shih-Yin
Chen, Cheng-Hsu
Huang, Yu-Chuen
Chan, Chia-Jung
Chen, Da-Chung
Tsai, Fuu-Jen
Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title_full Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title_fullStr Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title_full_unstemmed Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title_short Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
title_sort genetic susceptibility to idiopathic membranous nephropathy in high-prevalence area, taiwan
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265015/
https://www.ncbi.nlm.nih.gov/pubmed/25520922
http://dx.doi.org/10.7603/s40681-014-0009-y
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