Pediatric anti-NMDA receptor encephalitis is seasonal

In the majority of pediatric anti-N-methyl-d-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to di...

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Detalles Bibliográficos
Autores principales: Adang, Laura A, Lynch, David R, Panzer, Jessica A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265063/
https://www.ncbi.nlm.nih.gov/pubmed/25540806
http://dx.doi.org/10.1002/acn3.100
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author Adang, Laura A
Lynch, David R
Panzer, Jessica A
author_facet Adang, Laura A
Lynch, David R
Panzer, Jessica A
author_sort Adang, Laura A
collection PubMed
description In the majority of pediatric anti-N-methyl-d-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to disease etiology, particularly season of onset. In this retrospective case review study, we analyzed data from the 29 pediatric subjects with anti-NMDAR antibodies and found that symptoms were first reported in the warm months of April–September in 78% of non-tumor-related NMDARe (NT-NMDARe) cases. These findings support further investigation into a possible seasonal trigger of NT-NMDARe.
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spelling pubmed-42650632014-12-24 Pediatric anti-NMDA receptor encephalitis is seasonal Adang, Laura A Lynch, David R Panzer, Jessica A Ann Clin Transl Neurol Brief Communications In the majority of pediatric anti-N-methyl-d-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to disease etiology, particularly season of onset. In this retrospective case review study, we analyzed data from the 29 pediatric subjects with anti-NMDAR antibodies and found that symptoms were first reported in the warm months of April–September in 78% of non-tumor-related NMDARe (NT-NMDARe) cases. These findings support further investigation into a possible seasonal trigger of NT-NMDARe. BlackWell Publishing Ltd 2014-11 2014-10-30 /pmc/articles/PMC4265063/ /pubmed/25540806 http://dx.doi.org/10.1002/acn3.100 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Adang, Laura A
Lynch, David R
Panzer, Jessica A
Pediatric anti-NMDA receptor encephalitis is seasonal
title Pediatric anti-NMDA receptor encephalitis is seasonal
title_full Pediatric anti-NMDA receptor encephalitis is seasonal
title_fullStr Pediatric anti-NMDA receptor encephalitis is seasonal
title_full_unstemmed Pediatric anti-NMDA receptor encephalitis is seasonal
title_short Pediatric anti-NMDA receptor encephalitis is seasonal
title_sort pediatric anti-nmda receptor encephalitis is seasonal
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265063/
https://www.ncbi.nlm.nih.gov/pubmed/25540806
http://dx.doi.org/10.1002/acn3.100
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