Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice

OBJECTIVE: The hypothalamus is the brain center that controls the energy balance. Anorexigenic proopiomelanocortin (POMC) neurons and orexigenic AgRP neurons in the arcuate nucleus of the hypothalamus plays critical roles in energy balance regulation. FoxO1 is a transcription factor regulated by ins...

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Detalles Bibliográficos
Autores principales: Susanti, Vina Yanti, Sasaki, Tsutomu, Yokota-Hashimoto, Hiromi, Matsui, Sho, Lee, Yong-Soo, Kikuchi, Osamu, Shimpuku, Mayumi, Kim, Hye-Jin, Kobayashi, Masaki, Kitamura, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Brief Cutting Edge Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265245/
https://www.ncbi.nlm.nih.gov/pubmed/25044690
http://dx.doi.org/10.1002/oby.20838

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