Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid

BACKGROUND: Acute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential of FA as treatment modality for cardiac I/R. METHODS: Dependency of FA protect...

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Detalles Bibliográficos
Autores principales: Zuurbier, Coert J, Heinen, Andre, Koeman, Anneke, Stuifbergen, Roy, Hakvoort, Theodorus BM, Weber, Nina C, Hollmann, Markus W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265322/
https://www.ncbi.nlm.nih.gov/pubmed/25432364
http://dx.doi.org/10.1186/s12967-014-0325-8

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