The effect of UGTs polymorphism on the auto-induction phase II metabolism-mediated pharmacokinetics of dihydroartemisinin in healthy Chinese subjects after oral administration of a fixed combination of dihydroartemisinin-piperaquine

BACKGROUND: Dihydroartemisinin (DHA) is a component of artemisinin-based combination therapy (ACT), which is widely recommended for treatment of uncomplicated falciparum malaria. DHA is also the main metabolite of artemether and artesunate, both of which are used in ACT. Due to auto-induction metabo...

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Detalles Bibliográficos
Autores principales: Zang, Meitong, Zhu, Fanping, Zhao, Lixia, Yang, Aijuan, Li, Xinxiu, Liu, Huixiang, Xing, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265406/
https://www.ncbi.nlm.nih.gov/pubmed/25476790
http://dx.doi.org/10.1186/1475-2875-13-478

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