Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

BACKGROUND: There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage. Here, we investigated whether epigenetic silencing of Wnt antagonists is the b...

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Detalles Bibliográficos
Autores principales: Silva, Ana-Luisa, Dawson, Sarah N, Arends, Mark J, Guttula, Kiran, Hall, Nigel, Cameron, Ewen A, Huang, Tim H-M, Brenton, James D, Tavaré, Simon, Bienz, Mariann, Ibrahim, Ashraf EK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265460/
https://www.ncbi.nlm.nih.gov/pubmed/25432628
http://dx.doi.org/10.1186/1471-2407-14-891

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