Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration

INTRODUCTION: To investigate if decreased histone deacetylase 4 (HDAC4) is associated with human osteoarthritis (OA) cartilage degeneration by releasing HDAC4 inhibition of runt-related transcription factor-2 (Runx2) resulting in increase of OA cartilage degeneration-related genes. METHODS: The mRNA...

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Detalles Bibliográficos
Autores principales: Cao, Kun, Wei, Lei, Zhang, Zhiqiang, Guo, Li, Zhang, Congming, Li, Yongping, Sun, Changqi, Sun, Xiaojuan, Wang, Shaowei, Li, Pengcui, Wei, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265470/
https://www.ncbi.nlm.nih.gov/pubmed/25424126
http://dx.doi.org/10.1186/s13075-014-0491-3

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