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Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

BACKGROUND: Disease associated alterations in the phenotype of lamina cribrosa (LC) cells are implicated in changes occurring at the optic nerve head (ONH) in glaucoma. Lipofuscin, the formation of which is driven by reactive oxygen species (ROS), is an intralysosomal, non-degradable, auto-fluoresce...

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Detalles Bibliográficos
Autores principales:	McElnea, Elizabeth M, Hughes, Emily, McGoldrick, Aloysius, McCann, Amanda, Quill, Barry, Docherty, Neil, Irnaten, Mustapha, Farrell, Michael, Clark, Abbot F, O’Brien, Colm J, Wallace, Deborah M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265474/ https://www.ncbi.nlm.nih.gov/pubmed/25444463 http://dx.doi.org/10.1186/1471-2415-14-153

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