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An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point

Clarifying the intrinsic mechanisms of acupuncture's clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided...

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Autores principales: Shan, Yi, Wang, Zhi-qun, Zhao, Zhi-lian, Zhang, Mo, Hao, Shi-lei, Xu, Jian-yang, Shan, Bao-ci, Lu, Jie, Li, Kun-cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265514/
https://www.ncbi.nlm.nih.gov/pubmed/25525442
http://dx.doi.org/10.1155/2014/103491
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author Shan, Yi
Wang, Zhi-qun
Zhao, Zhi-lian
Zhang, Mo
Hao, Shi-lei
Xu, Jian-yang
Shan, Bao-ci
Lu, Jie
Li, Kun-cheng
author_facet Shan, Yi
Wang, Zhi-qun
Zhao, Zhi-lian
Zhang, Mo
Hao, Shi-lei
Xu, Jian-yang
Shan, Bao-ci
Lu, Jie
Li, Kun-cheng
author_sort Shan, Yi
collection PubMed
description Clarifying the intrinsic mechanisms of acupuncture's clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into real acupoint (21 subjects) and sham acupoint (10 subjects) groups. Our study used a single block experimental design to avoid the influence of posteffects. Functional magnetic resonance imaging data were acquired during acupuncture stimulation. Results showed extensive increase in neuronal activities with Siguan acupuncture and significant differences between stimulation at real and sham points. Brain regions that were activated more by real acupuncture stimulation than by sham point acupuncture included somatosensory cortex (the superior parietal lobule and postcentral gyrus), limbic-paralimbic system (the calcarine gyrus, precuneus, cingulate cortex, and parahippocampal gyrus), visual-related cortex (the fusiform and occipital gyri), basal ganglia, and the cerebellum. In this way, our study suggests Siguan may elicit specific activities in human brain.
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spelling pubmed-42655142014-12-18 An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point Shan, Yi Wang, Zhi-qun Zhao, Zhi-lian Zhang, Mo Hao, Shi-lei Xu, Jian-yang Shan, Bao-ci Lu, Jie Li, Kun-cheng Evid Based Complement Alternat Med Research Article Clarifying the intrinsic mechanisms of acupuncture's clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into real acupoint (21 subjects) and sham acupoint (10 subjects) groups. Our study used a single block experimental design to avoid the influence of posteffects. Functional magnetic resonance imaging data were acquired during acupuncture stimulation. Results showed extensive increase in neuronal activities with Siguan acupuncture and significant differences between stimulation at real and sham points. Brain regions that were activated more by real acupuncture stimulation than by sham point acupuncture included somatosensory cortex (the superior parietal lobule and postcentral gyrus), limbic-paralimbic system (the calcarine gyrus, precuneus, cingulate cortex, and parahippocampal gyrus), visual-related cortex (the fusiform and occipital gyri), basal ganglia, and the cerebellum. In this way, our study suggests Siguan may elicit specific activities in human brain. Hindawi Publishing Corporation 2014 2014-11-26 /pmc/articles/PMC4265514/ /pubmed/25525442 http://dx.doi.org/10.1155/2014/103491 Text en Copyright © 2014 Yi Shan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shan, Yi
Wang, Zhi-qun
Zhao, Zhi-lian
Zhang, Mo
Hao, Shi-lei
Xu, Jian-yang
Shan, Bao-ci
Lu, Jie
Li, Kun-cheng
An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title_full An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title_fullStr An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title_full_unstemmed An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title_short An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point
title_sort fmri study of neuronal specificity in acupuncture: the multiacupoint siguan and its sham point
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265514/
https://www.ncbi.nlm.nih.gov/pubmed/25525442
http://dx.doi.org/10.1155/2014/103491
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