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PTIP associates with Artemis to dictate DNA repair pathway choice

PARP inhibitors (PARPis) are being used in patients with BRCA1/2 mutations. However, doubly deficient BRCA1(−/−)53BP1(−/−) cells or tumors become resistant to PARPis. Since 53BP1 or its known downstream effectors, PTIP and RIF1 (RAP1-interacting factor 1 homolog), lack enzymatic activities directly...

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Detalles Bibliográficos
Autores principales:	Wang, Jiadong, Aroumougame, Asaithamby, Lobrich, Markus, Li, Yujing, Chen, David, Chen, Junjie, Gong, Zihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265673/ https://www.ncbi.nlm.nih.gov/pubmed/25512557 http://dx.doi.org/10.1101/gad.252478.114

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