HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner. Appropr...

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Detalles Bibliográficos
Autores principales: Rai, Taranjit Singh, Cole, John J., Nelson, David M., Dikovskaya, Dina, Faller, William J., Vizioli, Maria Grazia, Hewitt, Rachael N., Anannya, Orchi, McBryan, Tony, Manoharan, Indrani, van Tuyn, John, Morrice, Nicholas, Pchelintsev, Nikolay A., Ivanov, Andre, Brock, Claire, Drotar, Mark E., Nixon, Colin, Clark, William, Sansom, Owen J., Anderson, Kurt I., King, Ayala, Blyth, Karen, Adams, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265675/
https://www.ncbi.nlm.nih.gov/pubmed/25512559
http://dx.doi.org/10.1101/gad.247528.114

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